A study published by the University of Edinburgh in the United Kingdom showed that the intake of flavanols, quercetin, helps reduce the risk of children with ADHD by preventing nerve damage. Studies have found that certain fruits and vegetables help prevent nerve damage associated with spinal muscular atrophy (SMA), thereby reducing the risk of childhood hyperactivity (ALS).
In this study, the researchers established a zebrafish model and a mouse model of SMA, and identified the key molecular pathways that are responsible for controlling nerve and systemic pathways in SMA. Studies have found a wide range of stable disturbances in the ubiquitin protein, including the decrease of ubiquitin-like protein-modifying active enzyme 1 (UBA1) and the physiological interaction between surviving motor neuron (SMN) protein and UBA1 in the nerve. Studies have noticed that inhibiting UBA1 is sufficient to produce a neuromuscular condition similar to SMA, which indicates that UBA1 directly affects the process of counting. Disorders of UBA1 control and subsequent ubiquitin protein pathways can cause beta-connexin accumulation. Eliminating the accumulation of beta-connexin in cells can stably eliminate the neural response similar to SMA, thereby reversing this process. Increasing the intake of quercetin can inhibit nerve damage and inhibit the accumulation of beta-catenin in cells, thereby improving the occurrence of SMA.
This study is of great significance to people suffering from SMA and their families, and can significantly improve their quality of life. Although quercetin cannot prevent all the symptoms related to SMA, it can be used as a good aid in the early stage of SMA.