Chemical name: （+/-）-4’’,5,7-Thihyydroxy flavanone; （+/-）-naringenin; naringetol
Molecular formula: C15H12O5
Molecular wight: 272.25
Appearance: white crystalline fine powder
Analytical method: HPLC
Product original: Citrus paradis osbeck
Application: Naringenin is a potent inhibitor of the cytochrome p450 liver enzymes: CYP1A2, CYP3A3 and CYP3A4. There is however, considerable inter-individual variability in the effects of grapefruit juice on drug metabolism, in part due to 1) amount of naringenin formed by an individual, 2) amount of naringin present in a brand of grapefruit juice, 3) dilution of grapefruit juice used, and 4) other substances in grapefruit juice accounting for the interaction.2 Researchers at the University of Western Ontario in London discovered, while using various juices to hide the taste of a test substance given to patients along with their drugs as part of a cancer trial, that there was a synergistic or more effective action of the drug to breast cancer when it was given with Grapefruit Juice. From here, researchers launched studies of other fruits to find out why, and this is what they discovered. Human breast cancer cells in test tubes that were estrogen-insensitive; that is, the cells did not need estrogen to cock and prime them into maligency, respond well to a flavonoid found in grape juice, naringenin. Naringenin proved almost 8 times more potent at halting breast cancer cells's growth than another flavonoid, genestein from soy beans.